Vol 24, No 3 (2020)

Articles
MATHEMATICAL MODELLING OF APPLANATION LOADING OF THE EYEBALL WITH ACCOUNT FOR THE NONLINEARITY OF THE ELASTIC PROPERTIES OF THE CORNEA
Moiseeva I.N., Stein A.A.

Abstract

Mathematical modelling of the deformation of the eyeball loaded by a heavy stamp with a flat base is performed, which corresponds to Maklakoff tonometry. The modelling is carried out within the framework of the general approach developed by the authors, which represents the eyeball as a set of a deformable two-dimensional surface (cornea) and a zero-dimensional element that responds with a change in volume to changes in intraocular pressure (scleral region). The behavior of both components is assumed to be elastic: linear for the scleral region and non-linear for the cornea. For the latter, an exponential model developed by the authors was used, in which the nonlinearity of the elastic properties of the cornea is characterized by a single parameter. The calculations were carried out in the range of values of the nonlinearity parameter, estimated on the basis of data on tension of an isolated cornea by pressure. It is shown that taking into account the nonlinearity leads to an increase in the difference between the pressures in a loaded and unloaded eye (tonometric difference) and an increase in the slope of the dependence of tonometric pressure on the tonometer weight (pressure difference coefficient) during elastotonometry. The calculated corrections make it possible to propose refinements for the procedure of processing clinical measurement data. However, such conclusions should be considered as preliminary: there are no final estimates of the nonlinearity parameter for living eyes and they should be obtained as a result of comparing the calculation results with clinical studies. In particular, it is necessary to find out to what extent the values of this parameter are individual and may differ for different eyes.
Russian Journal of Biomechanics. 2020;24(3):272-281
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NANOINDENTATION AND SURFACE CHARACTERIZATION OF CLINICALLY RETRIEVED MULTI-FORCE NiTi ORTHODONTIC ARCHWIRES
Cherneva S., Stoyanova-Ivanova A., Gueorguieva M., Andreeva L., Petkov A., Petrov V., Petrova V., Mikli V.

Abstract

Nickel-titanium (NiTi) alloys, due to their properties of superelasticity and shape memory effect, have been extensively used in orthodontic treatment. Their superelasticity allows the orthodontist to apply an almost continuously low force with larger activation that reduces tissue trauma and patient discomfort, and thus facilitates tooth movement. The producers usually do not give information about the mechanical properties of the archwires they produce on their packagings or Web pages, which makes it difficult for the dentists to choose the most suitable material and with better cost-benefit for use. In the present work we investigated and compared the mechanical and physicochemical properties of as received and used for 6 and for 9 weeks multi-force NiTi archwires, produced by American Orthodontics under the trademark TriTanium TM, to evaluate if there are changes in their properties with clinical usage. The mechanical properties were investigated using nanoindentation measurements. The surface morphology and the elemental composition of the archwires were studied by scanning electron microscopy (SEM) and energy-dispersive analysis (EDS), respectively. The comparison of mechanical properties of as received and used for 6 and 9 weeks TriTanium TM archwires showed that their indentation hardness and modulus decrease with increasing of the time for use. No significant change in the elemental composition of the archwires was observed after their clinical application.
Russian Journal of Biomechanics. 2020;24(3):282-299
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EXPERIMENTAL SUBSTANTIATION OF THE USE OF INTELLIGENT SENSOR SYSTEMS IN THE ASSESSMENT OF BIOMECHANICAL PARAMETERS OF SPORT MOVEMENTS
Vassiouk V.E., Guseinov D.I., Davydova N.S., Lukashevich D.A., Minchenya A.V.

Abstract

The paper describes the design and software features of an intelligent sensor mounted on the oar shaft to register dynamic parameters characterizing the athlete’s interaction with the oar and the surface of the water in the supporting (water) part of the stroke. As a result of the study, experimental data were obtained, an algorithm was developed to analyze the strain-load curve and calculate the components of the resulting force applied to the oar during rowing. Based on a review of the literature corresponding to the research problem, as well as the data obtained during the pilot experiment, the prospects of using intelligent sensor systems as a means of quantitative description of the performance of sports movements in natural conditions are proved. The presented mathematical algorithm for calculating the values of the individual components of the resulting effort allows us to evaluate the ratio of the efforts made by the athlete and the resulting load on the paddle blades. The results allow us to conclude that the use of the method of mobile wireless tensometry for assessing the biomechanical parameters of sports movements is promising. Ways of further improvement of the developed methodology are determined.
Russian Journal of Biomechanics. 2020;24(3):300-311
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ANALYSIS OF MORPHOMETRIC AND FRACTAL PROPERTIES OF PHASE-CONTRAST IMAGES OF NATIVE AND APOPTOTICALLY CHANGED MCF-7 CELLS
Bayandin Y.V., Nikitiuk A.S., Voronina A.O., Beloglazova Y.A., Gagarskikh O.N., Grishko V.V., Naimark O.B.

Abstract

The aim of this work is to determine the morphometric and fractal characteristics of native and apoptotic MCF-7 cells based on the analysis of phase-contrast images obtained using laser interference microscopy. MCF-7 cells were cultured under standard conditions. Phase images of cells were obtained using a laser interference microscope MIM-340 at the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences. In the work, 30 native MCF-7 cells and 30 MCF-7 cells apoptotically changed under the influence of doxorubicin were studied. As a result of processing, the obtained phase images, the cell contour was estimated, which was used to determine the morphometric parameters and the fractal dimension of the cell phase image contour. The maximum and minimum diameters, perimeter and volume of the cell phase image were chosen as the geometric characteristics of the cell phase image. The fractal dimension of the phase image contour was calculated as a scale-invariant indicator characterizing the ruggedness of the cell contour. Comparative analysis of the morphology of native and apoptotic MCF-7 cells made it possible to differentiate the studied cells using the two-sample non-parametric Wilcoxon-Mann-Whitney test.
Russian Journal of Biomechanics. 2020;24(3):312-322
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THE PROBLEM OF MUTUAL ORIENTATION DETERMINATION OF THE ACCELEROMETER UNIT RELATIVE TO TARGET OF THE MOTION CAPTURE SYSTEM
Kruchinin P.A., Latonov V.V., Matveev D.S.

Abstract

Two algorithms for determination of the rotation matrix of the inertial unit relative to the motion capture 6DOF target are discussed. Solution of this problem is necessary for further co-operative data processing of these sensors in biomechanical researches. In particular, it is required to estimate the acceleration of a moving object in the field of gravity from the data of a 3D accelerometer and a motion capture system. In this case, the local vertical of the well calibrated motion capture system can be used to separate the gravity induced components from the accelerometer data. Both algorithms use measurements obtained for static positions, which differ in orientation of instrumental axes relative to gravitational vertical and at the same time allow us to estimate systematic errors of accelerometers. The first algorithm assumes orthogonality of instrumental axes of inertial unit and does not take into account errors in information on scale coefficients of accelerometers. The algorithm uses equations wich are linearized in the neighborhood of a priori estimates of the unknown values. The second algorithm does not use a priori information about axes of instrumental frame. In this case, the accelerometer unit is recalibrated, and in addition to the zeros and scale factors, the non-orthogonal angles of the instrumental axes of the unit are determined. The immediate result of its work is a matrix, which allows us to determine projections of apparent acceleration on body axes of the motion capture system. Algorithms are tested on experimental data. The comparison criteria is the repeatability of estimated results obtained from different measurement samples. Processing the results of the trial experiment showed that for inaccurate microelectromechanical systems, the second algorithm produced more stable results.
Russian Journal of Biomechanics. 2020;24(3):323-329
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EXPERIMENTAL STUDY OF THE PROPERTIES OF THE BASE OF A NOVEL COMBINED FULL LAMINAR OVERDENTURE
Astashina N.B., Bazhin A.A., Kachenyuk M.N., Sergeyeva E.S., Kazakov S.V., Rogozhnikova E.P., Baydarov A.A., Nikitin V.N.

Abstract

This research is targeted at experimental study of the properties of the base of a newly-designed combined full laminar overdenture which is used in fully edentulous patients. The design is novel in that a framework ( Bicon LLC , Boston, USA) made of a fibreglass-based composite (for example, Trinia ). It is introduced into the base of a full laminar overdenture which is made of an acrylic resin. To substantiate performance of the proposed design and of subsequent modeling of biomechanical behaviour of the of the novel combined dental design, properties of the following base specimens were subjected to comparative study: 1 - poly(methyl methacrylate)-based acrylic resin; 2 - mesh-reinforced poly(methyl methacrylate)-based acrylic resin, Renfert (Germany); 3 - Trinia -framework poly(methyl methacrylate)-based acrylic resin. The experimental studies determined that, when combined with Trinia ( Bicon LLC , Boston, USA), the base resin demonstrates excellent strength properties, considerably better than in the existing counterparts. Furthermore, metal mesh showed low performance when used to reinforce full laminar overdenture base. The findings will allow us to proceed with biomechanical modelling and to look into distribution patterns of functional loads which develop at the basal seat when a full laminar overdenture is used, and to determine optimum parameters for the structural components of the newly-designed combined full laminar overdenture.
Russian Journal of Biomechanics. 2020;24(3):330-343
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INDENTATION OF A CYLINDER WITH DIFFERENT SHAPE OF THE BASE INTO VISCOELASTIC HALF-SPACE
Yakovenko A.A.

Abstract

During developing medical equipment and processing results of experiments on the study of biomaterials, it is necessary to describe the process of interaction of the working tool with soft tissues. With this, it is important to take into account not only the mechanical properties of the tissue under study, but also the technical characteristics of the equipment, such as the shape of the tool surface and the speed of the interaction process. For this purpose, a contact model describing the indentation of an axisymmetric rigid cylinder with different foundation surface shape into viscoelastic half-space at a constant speed was constructed. The theory of linear viscoelasticity was used to describe the mechanical behavior of the half-space. A three-parameter model of a standard viscoelastic body was chosen as a viscoelastic model that defines the type of relaxation function of the half-space material. The distribution of contact pressure under the cylinder surface and the dependence of the applied load on the depth of indentation for various forms of the contact surface of the cylinder were obtained. The influence of the shape of the cylinder base surface, the indentation speed and the relaxation properties of the half-space on the characteristics of the contact interaction was studied. For describing the mechanical behavior of biological tissues, a one-dimensional model of a standard viscoelastic body was also considered. For this simplified model, the distribution of the contact pressure under the surface of cylinder with different shape of the base and the dependence of the applied load on time were also obtained. The results obtained using the continuous model and the one-dimensional model were compared. It was shown when it is more appropriate to use the simplified models to describe the interaction of an instrument with biological tissue.
Russian Journal of Biomechanics. 2020;24(3):344-363
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THE MECHANICAL PROPERTIES OF THE SYSTEM BONE-IMPLANT SYSTEMS
Minasov T.B., Scriabin V.L., Sotin A.V., Minasov I.B., Saubanov R.A., Fayzullin A.A., Vakhitov-Kovalevich R.M.

Abstract

Fractures of the diaphysis of leg bones make up 45 % of all long bone fractures, they are one the most common injuries to the bones of the limb segments, the treatment of which is accompanied by a large number of complications, therefore the problem of improving the treatment of patients with this injury is still relevant for present traumatology and orthopedics. The use of compression distraction systems, intramedullary and extramedullary osteosynthesis systems allows a stable functional osteosynthesis and eliminates the need for additional gypsum immobilization of a segment or limb in the postoperative period. Biomechanical relations in the bone-implant system in conditions of a stable functional osteosynthesis constitute an important factor allowing to objectify the mode of motion rehabilitation in the early postoperative period. This work studies the results of the comparative bench tests of groups of cadaver tibia in experimental injuries of type 42 A 1.1. (according to the Association for Study of Internal Fixation ( AO / ASIF) ) synthesized with different types of implants, such as Fixion expanding system of fixation, external fixation devices, limited contact dynamic compression plate (LC-DCP) and blocked intramedullary osteosynthesis system (BIOS)). Each system was axially compressed using INSTRON 1185. Resistance to axial compression has been analyzed. It is noted that all these types of fixations increase the strength of the systems in the range of 22-81 % compared to the intact specimens. Intraosseous fixation systems demonstrated the highest strength, which has the most optimal biomechanical relations in the bone-implant system, allowing to objectify the regime of motion rehabilitation.
Russian Journal of Biomechanics. 2020;24(3):364-369
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BIOMECHANICAL MODELLING OF THE TEMPOROMANDIBULAR JOINT FORCES INFLUENCE ON THE INTERNAL CAROTID ARTERY
Tverier V.M., Shitoev I.D., Nyashin Y.I.

Abstract

Currently, cardiovascular diseases in many cases can cause premature death (up to 40 % of deaths). In the literature, there are observations about the effect of the temporomandibular joint dysfunction on the state of the cervical portion of the internal carotid artery. Under the influence of the load in the joint, bends and, possibly, looping are formed in the artery, which lead to a decrease in the volume of cerebral circulation and the development of a stroke. To date, there is no strict description of the maxillofacial influence in general and the temporomandibular joint in particular on the brain nutrition, which for the most part goes through the internal carotid artery (up to 80 % of the total blood volume). For the quantitative assessment of the loads influence on blood flow, the model example is considered, and it is shown the 34 % decrease in the carotid artery opening due to forces in the temporomandibular joint. To confirm the hypothesis and explain the action of the effect of loads, it is necessary to develop the biomechanical model of the internal carotid artery and the temporomandibular joint interaction. This study is complicated by the variability of the living structures characteristics from person to person. In the article, it is provided the detailed description of this problem, proposed the formulation of the loading coupled problem on the branch of the carotid artery by forces in the joint and blood flow in this part of the artery and the algorithm for solving this problem through averaging and simpifying the model. The iterative procedure for interaction in the elasticity theory problems and the averaged blood flow problem are presented.
Russian Journal of Biomechanics. 2020;24(3):370-389
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DISTRIBUTION OF BLOOD COMPONENTS IN THE POISEUILLE FLOW
Fedoseev V.B.

Abstract

The thermodynamic approach is used to describe the stationary distributions of blood components in a cylindrical Poiseuille flow. Based on it, a method is described for numerical modelling of the distribution of blood components over the blood vessel cross-section. Dispersed phases are represented by a combination of cellular components (red blood cells, white blood cells, etc.), blood plasma is considered as a low molecular weight dispersion medium. The distributions are obtained on the basis of the invariance condition of mechanochemical potentials (the sum of the chemical potential and mechanical energy) of the components, which is fulfilled at stationary equilibrium in stationary external fields of different nature. The calculation is reduced to a numerical search for a solution to a system of transcendental equations corresponding to the continuity of the medium. This system has a unique solution that describes the consistent distributions of all the components of a multiphase flow over the cross-section. It is shown that at the Poiseuille flow, the distributions of the individual dispersed phases can have up to three symmetrical extrema, the position of which is determined by the flow conditions (shear rate, vessel diameter, blood composition). As a demonstration of the model’s capabilities, the distribution of blood components (erythrocytes, platelets, lymphocytes) for vessels with a diameter of 0.1 to 5 mm at shear rates from 1 to 100 s-1 is given. It is shown that there is a very complex relationship between flow parameters (shear rate, diameter of a blood vessel) and blood composition. Unlike most hydrodynamic models of two-phase flows, the thermodynamic approach allows one to consider the distributions of an arbitrary set of dispersed and low molecular weight blood components, including foreign ones.
Russian Journal of Biomechanics. 2020;24(3):390-397
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